ire 1 3294 (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc
ire 1 3294
Ire 1 3294, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 42335 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+irs+1/Caspase-3+Antibody/us12589088-616-15-17
Average 99 stars, based on 42335 article reviews
Ire 1 3294, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 42335 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+irs+1/Caspase-3+Antibody/us12589088-616-15-17
Average 99 stars, based on 42335 article reviews
ire 1 3294 - by Bioz Stars,
2026-10
99/100 stars
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Bioprocessing:Article Title: Spatiotemporal Expression of IRS-1 During Brain Development and its Role in Neural Stem Cell Differentiation. Article Snippet: Insulin receptor substrate 1 (IRS-1) is a key mediator of insulin signaling linked to focal cortical dysplasia.. While previous studies have primarily focused on IRS-1 in peripheral tissues, its function in the central nervous system has remained largely unexplored.. This study aimed to investigate the spatiotemporal expression patterns of IRS-1 protein in mouse cerebral cortex and human brain organoids, along with its role in neural development. other:Article Title: Camel milk endogenous peptides ameliorated hyperglycemia in high-fat diet-fed C57BL/6 J mice in association with modulation of gut microbiota and the IRS/Akt and JNK/p38 pathways. Article Snippet: The hypoglycemic activity of camel milk are garnering significant and growing attention.. In this study, the effect of camel milk endogenous peptides (CMEP) on the hyperglycemia in high-fat diet fed C57BL/6 J mice was studied.. Our results exhibited that CMEP ameliorated body weight gain, hyperglycemia and hyperinsulinemia, mitigated dyslipidemia and systemic inflammation, increased the short-chain fatty acids level, repaired the gut microbiota disorders, and decreased the intestinal permeability by boosting the zonula occluden 1 (ZO-1), claudin and occludin protein expressions in high-fat diet-fed mice. Blocking Assay:Article Title: Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway Article Snippet: Protein samples were separated on 10% or 12% SDS-PAGE gels and then transferred to polyvinylidene difluoride (PVDF; Millipore, MA, United States) membranes. .. After blocking with 5% skimmed milk, the PVDF membranes underwent overnight incubation at 4 °C with the following primary antibodies: anti-phospho-IRS-1 (ser307) (1:1,000, 2,381, CST), Article Title: Intrabody targeting of insulin receptor pY1150: A novel approach to modulate signaling pathways in colorectal cancer cells. Article Snippet: The activation of the insulin receptor (IR) is central to the regulation of physiological metabolism, growth, and proliferation, and is associated with various cancers, including colorectal cancer (CRC).. Among the tyrosine residues in the intracellular kinase domain of IR, Tyr1150 plays a pivotal role in receptor activation by regulating substrate binding to the kinase active site.. In this study, we introduce a novel approach for selectively modulating insulin signaling in CRC through the development of an intrabody targeting phosphorylated Tyr1150 (IR pY1150). Incubation:Article Title: Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway Article Snippet: Protein samples were separated on 10% or 12% SDS-PAGE gels and then transferred to polyvinylidene difluoride (PVDF; Millipore, MA, United States) membranes. .. After blocking with 5% skimmed milk, the PVDF membranes underwent overnight incubation at 4 °C with the following primary antibodies: anti-phospho-IRS-1 (ser307) (1:1,000, 2,381, CST), Article Title: Intrabody targeting of insulin receptor pY1150: A novel approach to modulate signaling pathways in colorectal cancer cells. Article Snippet: The activation of the insulin receptor (IR) is central to the regulation of physiological metabolism, growth, and proliferation, and is associated with various cancers, including colorectal cancer (CRC).. Among the tyrosine residues in the intracellular kinase domain of IR, Tyr1150 plays a pivotal role in receptor activation by regulating substrate binding to the kinase active site.. In this study, we introduce a novel approach for selectively modulating insulin signaling in CRC through the development of an intrabody targeting phosphorylated Tyr1150 (IR pY1150). |